Recently, professors Wang Chao and Liu Zhuang from the FUNSOM of our university have published a paper titled "Oral administration of garlic-derived nanoparticles improves cancer immunotherapy by inducing intestinal IFNγ-producing γδ T cells" in Nature Nanotechnology.
The study reveals that GNPs significantly enhance the proliferation and activation of endogenous γδ T cells in the intestine, leading to a substantial increase in IFN-γ production. Furthermore, the the levels of the chemokine receptor CXCR3 in γδ T cells in mice’s intestine were elevated through the treatment of GNPs, driving their migration from the intestine to the tumor environment. The γδ T cells and IFNγ then translocate from the intestine to subcutaneous tumors outside the intestine, reshaping the tumor immune microenvironment and synergizing with anti-PD-L1 to induce a robust anti-tumor immune response. This research uncovers the potential complex mechanisms of interaction between the intestine and tumors, offering a novel method for γδ T cell-based immunotherapy. The related research findings were published online on July 25, 2024, with Xu Jialu, a former PhD student from our university, as the first author.
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